Table of Contents
- 1 Which factors affect the bioavailability of ophthalmic products?
- 2 What does for ophthalmic use only mean?
- 3 What are the characteristics required in an ideal ocular drug delivery system?
- 4 What are the characteristics of the reservoir or membrane devices?
- 5 Why is the packaging important for ophthalmic products?
- 6 Why is the development of ophthalmic drug forms important?
Which factors affect the bioavailability of ophthalmic products?
3.1. Factors affecting intraocular bioavailability
- Pre-corneal fluid drainage. Pre-corneal fluid drainage is one of the main reasons for low ocular drug absorption (4, 18).
- Drug binding to tear proteins.
- Systemic drug absorption.
- Corneal Factors.
- Melanin binding.
- Drug metabolism.
What does for ophthalmic use only mean?
This medication is used to treat ophthalmic (eye) infections. Ophthalmic means relating to or concerned with the medical care of people’s eyes.
What are the essential characteristics of eye drops?
Although we do not have precise knowledge of how certain drugs are chosen vs others, eye drop characteristics that may determine their use include potency, cost, ease of use, and adverse effects, both real and perceived.
Which product is available as an ophthalmic ointment?
Neosporin Ophthalmic Ointment is a prescription medicine used to treat the symptoms of Ocular Infection or Inflammation. Neosporin Ophthalmic Ointment may be used alone or with other medications. Neosporin Ophthalmic Ointment belongs to a class of drugs called Antibiotics, Ophthalmic Combos.
What are the characteristics required in an ideal ocular drug delivery system?
The following characteristics are required to optimize ocular drug delivery systems 7. A good corneal penetration. A prolonged contact time of drug with corneal tissue. Simplicity of installation and removal for the patient.
What are the characteristics of the reservoir or membrane devices?
What are the characteristics of the reservoir or membrane devices? Explanation: These devices are used when the drug permeation through the stratum corneum is rapid than the rate of drug diffusion from the device. It is suitable for drugs which have low therapeutic indices.
Is ophthalmic topical?
Tobramycin ophthalmic solution 0.3% is a topical antibiotic indicated in the treatment of external infections of the eye and its adnexa caused by susceptible bacteria. Appropriate monitoring of bacterial response to topical antibiotic therapy should accompany the use of tobramycin ophthalmic solution 0.3%.
Which is the best description of an ophthalmic product?
Ophthalmic anti-infectives are anti-infectives contained in a product formulated especially to be instilled or applied in the eye or eyes. These include eye drops, gels or ointments. Anti-infectives are drugs that can either kill an infectious agent or inhibit it from spreading.
Why is the packaging important for ophthalmic products?
Packaging must be adequate to protect ophthalmic preparations from light, moisture, microbial contamination, and damage due to handling and transportation. Ophthalmic preparations should maintain their integrity throughout their shelf-life when stored at the temperature indicated on the label.
Why is the development of ophthalmic drug forms important?
The primary purpose for the development of ophthalmic drug forms is to achieve the required drug concentration in the place of absorption and sustaining it for appropriately long time, which in turn contributes to smaller application frequency [ 1
How are ophthalmic preparations used in the eye?
Ophthalmic preparations: Definition: They are specialized dosage forms designed to be instilled onto the external surface of the eye (topical), administered inside (intraocular) or adjacent (periocular) to the eye or used in conjunction with an ophthalmic device.