Table of Contents
When do you draw gentamicin trough and peak?
Both peak and trough concentrations should be monitored. The trough sample is drawn immediately prior to the next dose. Peak samples should be drawn 45 to 60 minutes after an IM injection, 30 minutes after the end of a 30-minute IV infusion, or immediately after a 60-minute IV infusion.
What is gentamicin goal peak and trough?
The most commonly used dose is 80mg three times daily. Pre-dose (trough) gentamicin levels should be checked after 24 hours of treatment (target <2mg/L) and peak levels measured one hour post-dose (target 5–10mg/L). Some infections, such as. Pseudomonas spp. may require an increased dose to achieve higher peak levels.
What antibiotics require peak and trough dosing?
Antibiotics That Require Frequent Monitoring
- Antibiotics that Require Frequent Monitoring (Aminoglycosides)
- 35 mcg/ml Peaks 5 mcg/ml Troughs Amikacin Drugs.
- 10 mcg/ml Peaks 2 mcg/ml Troughs Gentamicin Drugs.
- 35 mcg/ml Peaks 5 mcg/ml Troughs Kanamycin Drugs.
- 16 mcg/ml Peaks 2 mcg/ml Troughs Neomycin Drugs.
What is gentamicin peak?
Peaks. 5-12. IV: 30 minutes after the end of the infusion. Gentamicin is a concentration-dependent, bactericidal antibiotic used for the treatment of gram-negative organisms including Pseudomonas, Escherichia coli, Proteus, and Serratia.
What is the peak for gentamicin?
Peak targets are generally between 5.0 and 8.0 mcg/mL for less severe infections and 8.0 and 10.0 mcg/mL for severe infections. Prolonged exposure to peak levels exceeding 12.0 mcg/mL may lead to toxicity.
How should gentamicin be administered?
Gentamicin injection comes as a liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle). When gentamicin is injected intravenously, it is usually infused (injected slowly) over a period of 30 minutes to 2 hours once every 6 or 8 hours.
Does IM gentamicin need to be diluted?
Injection, USP – 80 mg/2 mL – (40 mg/mL as Gentamicin) FOR INTRAVENOUS INFUSION OR INTRAMUSCULAR INJECTION – CAUTION: MUST BE DILUTED FOR INTRAVENOUS USE.
What medications require a peak and trough?
Therapeutic Drugs – Optimal Time to Draw Samples
| DRUG | DRAW TIMES |
|---|---|
| Aminoglycosides: Gentamicin & Tobramycin | IM Therapy: Draw trough just prior to next dose and peak at one hour after injection |
| Carbamazepine | Collect just prior to next dose |
| Digoxin | One determination is needed within 6 – 24 hours after the previous dose. |
Are the use of gentamicin?
Gentamicin injection is used to treat serious bacterial infections in many different parts of the body. Gentamicin belongs to the class of medicines known as aminoglycoside antibiotics. It works by killing bacteria or preventing their growth.
What is trough and peak level?
The trough level is the lowest concentration in the patient’s bloodstream, therefore, the specimen should be collected just prior to administration of the drug. The peak level is the highest concentration of a drug in the patient’s bloodstream.
When to check gentamicin trough?
Pre-dose (trough) gentamicin levels should be checked after 24 hours and then twice weekly (target <1mg/L). Peak gentamicin levels, taken one hour after administration, can also be measured (target 3–5mg/L). Individualised dosing based on the patient’s pharmacokinetics can also be used.
What is the vancomycin peak and trough?
Vancomycin, Peak and Trough – Vancomycin is an antibiotic used in the treatment of bacterial infections, especially methicillin-resistant staphylococci.
When to draw gentamicin trough?
The trough sample is drawn immediately prior to the next dose. Peak samples should be drawn 45 to 60 minutes after an IM injection , 30 minutes after the end of a 30-minute IV infusion , or immediately after a 60-minute IV infusion.
How often are gentamicin troughs?
The most commonly used dose is 80mg three times daily. Pre-dose (trough) gentamicin levels should be checked after 24 hours of treatment (target <2mg/L) and peak levels measured one hour post-dose (target 5–10mg/L). Some infections, such as Pseudomonas spp.may require an increased dose to achieve higher peak levels.