How do you treat clozapine drooling?

How do you treat clozapine drooling?

Data synthesis: Sialorrhea is a common and disabling adverse effect of clozapine use. Current treatment options include topical and oral antimuscarinic medications and α-adrenergic agents. New areas of investigation include glycopyrrolate, botulinum toxin, and substitute benzamide derivatives.

Is there an antidote for clozapine?

Clozapine is a rare cause of such toxicity. Physostigmine is a recognized antidote for central and peripheral signs and symptoms of the anticholinergic toxidrome, though it remains underused.

How do you treat clozapine toxicity?

Primary management of acute clozapine overdose is supportive care. Providers should be prepared to provide airway management given the frequency of somnolence and coma. Hypotension refractory to fluids may be present due to alpha-adrenergic blockade, and vasopressor support may be necessary.

Do clozapine side effects go away?

Some side effects of clozapine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Why does clozapine increase saliva?

Clozapine also increases pooling of saliva in the mouth by diminishing esophageal motility, which gives the appearance of hypersalivation as a result of reduced saliva clearance through normal swallowing. Excessive saliva secretion and pooling can be reduced by practical behavioral and/or pharmacologic interventions.

What causes drooling with clozapine?

A common side effect of clozapine is drooling or the appearance of excess saliva, also known as sialorrhea. This is caused by decreased swallowing, leading to increased saliva in the mouth. Drooling usually happens while sleeping, sometimes during the day. This is typically not a dangerous side effect.

What is clozapine toxicity?

Clozapine at toxic doses may cause hyperthermia, alterations in consciousness, seizures, cardiac arrhythmias, excessive mucus production in bronchi, hypersalivation, miosis, blood dyscrasias, pancreatitis and hepatitis (Sartorius et al., 2002).

How do you manage clozapine?

Patients taking clozapine should receive routine weekly-to-monthly monitoring and maintain an ANC ≥1500/microL (≥1000/microL for benign ethnic neutropenia). Lower ANC levels require more frequent monitoring, and possible interruption of clozapine and/or reevaluation of its use.

How do you treat haloperidol overdose?

These symptoms can be treated using a slow intravenous (IV) injection of 5 mg biperiden injection, which can be repeated after a few hours if needed. Oral or intramuscular biperiden may also need to be continued for several days or weeks.

What is the most serious side effect of clozapine?

Clozapine can cause serious heart problems. Call your doctor right away if you have chest pain, trouble breathing, fast or pounding heartbeats or sudden dizziness.

What is the treatment for hypersalivation?

Traditional treatment options include daily oral medications to diminish saliva production, periodic injections of a medication called Botox for temporary reduction in saliva production, or a variety of open surgical procedures to remove some salivary glands or disconnect others from the mouth.

Are there any medications that can reduce saliva production?

Certain medications can help decrease saliva production. Glycopyrrolate (Cuvposa) is a common option. This medication blocks nerve impulses to the salivary glands so that they produce less saliva. However, this medication can have some severe side effects, including:

Which is the best treatment for hypersalivation of the mouth?

Scopolamine (Hyoscine) is another option. This is a skin patch that’s placed behind the ear. It works by blocking nerve impulses to the salivary glands. Its side effects include: Your doctor may recommend botulinum toxin (Botox) injections if your hypersalivation is constant.

Why do you need to report side effects for Novartis products?

By reporting side effects for Novartis products you help us to ensure the safety of our products and our patients.

What to do if you have excessive saliva in your mouth?

If you find yourself having excessive saliva in your mouth, it’s essential to consult with your doctor to determine the best treatment plan.