How is metoprolol overdose treated?

How is metoprolol overdose treated?

The goal of therapy is to restore cardiac output. Good supportive care is important, in addition to the first line treatment for beta blocker overdose: high dose glucagon (see below). Give normal saline at 1 to 1½ times maintenance rate while avoiding fluid overload.

Is there a reversal agent for metoprolol?

Because it may bypass the beta-receptor site, glucagon can be considered as an alternative therapy for profound beta-blocker intoxications. The doses of glucagon required to reverse severe beta-blockade are 50 micrograms/kg iv loading dose, followed by a continuous infusion of 1-15 mg/h, titrated to patient response.

What happens if I take too much metoprolol?

Taking too much metoprolol can slow down your heart rate and make it difficult to breathe. It can also cause dizziness and trembling. The amount of metoprolol that can lead to an overdose varies from person to person.

Which drug is used in beta-blocker overdose?

Glucagon for the treatment of symptomatic beta blocker overdose. Emerg Med J 2003; 20:266. Lee J. Glucagon use in symptomatic beta blocker overdose.

How many mg of metoprolol is fatal?

The two fatal overdose levels were deter- mined to be 50 mg/L in blood and 120 mg/kg in liver (6), and 56 mg/L in blood, 42 mg/L in vitreous humor, 276 mg/L in bile, and 260 mg/kg in liver (7). Several analytical procedures for the determination of metoprolol in biological specimens have been reported (8-13).

What is the antidote for diltiazem?

Currently, there is no specific antidote and the treatment of CCB poisoning is supportive; however, this supportive therapy is often insufficient. We present a clinical case of severe diltiazem poisoning and the therapeutic approaches that were used.

How do you taper metoprolol?

Avoid abrupt discontinuation. Stopping metoprolol (both tartrate and succinate) suddenly can exacerbate angina and may increase the risk of a heart attack. Reduce dosage gradually over a few weeks as instructed by your doctor. May interfere slightly with laboratory cholesterol results.

How is metoprolol excreted?

Elimination is mainly by biotransformation in the liver, and the plasma half-life ranges from approximately 3 to 7 hours. Less than 5% of an oral dose of metoprolol is recovered unchanged in the urine; the rest is excreted by the kidneys as metabolites that appear to have no beta-blocking activity.

Is 50 mg of metoprolol too much?

The dose is usually 1 milligram (mg) per kilogram (kg) of body weight once a day. The first dose should not be more than 50 mg once a day. Your doctor may adjust your dose as needed.

How much beta-blocker is fatal?

Q6. What is the lethal dose of propranolol? Any ingested dose of propranolol > 1 g is considered to be potentially lethal.

Can I wean off metoprolol?

Don’t stop taking metoprolol suddenly. If you do, you may experience worse chest pain, a jump in blood pressure, or even have a heart attack. Stopping metoprolol is not recommended. If you need to stop taking the drug, first talk to your doctor.

Can an overdose of metoprolol cause death?

A beta-blocker overdose can be very dangerous. It can cause death. If the person’s heart rate and blood pressure can be corrected, survival is likely.