Table of Contents
Is ephedrine a strong or weak base?
Also, a salt such as ephedrine hydrochloride can be prepared between a weak base-ephedrine and a strong acid-hydrochloric acid.
Is ephedrine a weak acid?
Question: QUESTION 4 0.1 M ephedrine hydrochloride EpHCI (ephedrine is a weak base, pKa- 9.36, Reminder: because ephedrine is a base, ephedrine hydrochloride is a salt of strong acid and weak base) Answer pH QUESTION 5 0.165 M sodium sulfathiazole NaSz (sulfathiazole is a weak acid, Ka-7.6×10-8 Answer pH.
Is ephedrine sulfate a base?
Each mL contains ephedrine sulfate, USP 5 mg (equivalent to 3.8 mg ephedrine base), 0.9% sodium chloride, USP in water for injection. The pH is adjusted with sodium hydroxide and/or glacial acetic acid if necessary. The pH range is 4.5 to 7.0.
Is ephedrine hydrochloride acidic or basic?
Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine….Structure for Ephedrine hydrochloride (DBSALT001513)
| Property | Value | Source |
|---|---|---|
| pKa (Strongest Acidic) | 13.89 | ChemAxon |
| pKa (Strongest Basic) | 9.52 | ChemAxon |
Is ephedrine polar?
The no-polar structure of ephedrine makes this substance more liposoluble than catecholamines. It is thermodynamically more stable, in consequence, it is not a substrate for monoamineoxidase (MAO) or the catechol-O-methyltranspherase.
What is the difference between ephedrine HCL and Sulfate?
The difference between these formulations is not just in the type of salt, but also in the concentration or amount of that salt. Ephedrine sulfate is a heavier molecule, thus the ratio of free base to salt is greater. There is more ephedrine per mL of ephedrine sulfate than there is per mL of ephedrine hydrochloride.
Is ephedrine a vasoconstrictor?
Ephedrine and pseudoephedrine thus exert a vasoconstrictive effect on the vessels, which underlies the relief they procure in nasal congestion.
What is ephedrine soluble in?
Soluble in water, in alcohol, in chloroform, and in ether; sparingly and slowly soluble in mineral oil, the solution becoming turbid if the Ephedrine contains more than about 1% of water.
What is in ephedrine sulfate?
Ephedrine Sulfate Injection, USP is indicated in the treatment of allergic disorders, such as bronchial asthma. The drug has long been used as a pressor agent, particularly during spinal anesthesia when hypotension frequently occurs.
What’s the difference between ephedrine sulfate and ephedrine HCL?
What is the pH of ephedrine?
The pH range is 4.5 to 7.0. Ephedrine sulfate is a sympathomimetic amine that directly acts as an agonist at α- and ß adrenergic receptors and indirectly causes the release of norepinephrine from sympathetic neurons.
Is ephedrine direct or indirect acting?
Ephedrine is a synthetic noncatecholamine agonist at α, β1, and β2 receptors with both direct and indirect actions.
Which is a weak base of ephedrine sulfate?
Ephedrine sulfate is a salt of a weak base (ephedrine, Kb = 2.3 × 10 -5 ). We can determine that it is a salt of a weak base from the counter ion (sulfate, SO 4 -2, is negatively charged). Because sulfate has two negative charges then it associates with two protonated ephedrine ions (BH +) to form a 2:1 salt ( (BH +) 2SO 4 -2).
What are the properties of pure ephedrine in water?
Properties of Pure Ephedrine. Ephedrine was found to be very soluble in water, alcohol, and chloroform and nearly insoluble in petroleum ether upon cooling. Being a strong base, ephedrine displaces ammonia from its salts. Solutions of the salts in water varying from 1 to 10 percent were found to be exceedingly stable.
How are pseudoephedrine and HCl salts prepared?
Preparation of Pseudoephedrine. Boiled gently with reflux condenser for 12 hours. The acid solution was evaporated low over a water bath and allowed to crystallize; the crystallized HCl salt consisted of nearly pure unchanged ephedrine hydrochloride.
Which is a salt of a weak base?
Ephedrine sulfate is a salt of a weak base (ephedrine, Kb = 2.3 × 10-5 ). We can determine that it is a salt of a weak base from the counter ion (sulfate, SO4-2, is negatively charged).