What are the evaluation test for ointments?

What are the evaluation test for ointments?

The mechanical evaluation parameters like pH, viscosity, spreadability, homogeneity are important tests to evaluate pharmaceutical ointment formulations. The result of all the formulations near to pH 6.8±1 indicates better chemical compatibility of ointments with skin.

What are the quality control tests conducted in manufacturing ointments creams and gels?

Quality Control requirements for semi-solid dosage forms (Ointments, Creams, Jellies and Suppositories) Tests include: Evaluation for visual appearance, colour, odour, labelling, and homogeneity. Loss of water.

What are the methods by which you will evaluate injectables as a quality control pharmacist?

STERILITY TEST:- The test method for sterility of the product: Membrane filtration. Direct inoculation of the culture medium….Pass

• Gel clot method.
• Turbidimetric method.
• Chromogenic method.

What are the different types of ointments?

What Are Ointments?

• Petroleum jelly.
• Anhydrous lanolin.
• Waxes.
• Vegetable oils.
• Lard.

How is pH of ointment measured?

First, you have to make sure that the cream is o/w and not w/o. Only for the o/w sytem based products, you should do the pH of the finished product (as is) using a properly calibrated pH meter and then (5o% dilution with water.) This will give you the true pH of your product.

What is the formulation of ointment?

Typical ointment bases comprise petrolatum and mineral oil, or petrolatum and waxy/fatty alcohol combinations, the ratio and grades of these components being selected to give the desired finished product viscosity/spreadability.

What is sterility testing?

What is sterility testing? Sterility testing is designed to demonstrate the presence or absence of extraneous viable contaminating microorganisms in biological parenterals designed for human use. The sterility assay is 14 days allowing for an appropriate incubation period to detect slower-growing microorganisms.

Which tests are performed for evaluation of parenterals?

Basically there are test performed to detect the presence of pyrogens in sterile parenteral products they are C) Rabbit Test D) LAL Test….INTRODUCTION:

• Sterility Tests.
• Pyrogen Tests.
• Leaker Tests.
• Particulate matter testing.

What is a topical formulation?

Topical formulations are made up in a vehicle, or base, which may be optimised for a particular site of the body or type of skin condition. The product may be designed to be moisturising or to maximise the penetration of an active ingredient, often a medicine, into or through the skin.

What are the methods of preparing ointments?

Procedure for Preparation:

• Melt the stearyl alcohol and white petrolatum on a hot plate.
• Heat this mixture to 70°C.
• Dissolve remaining ingredients in water and heat the solution to 70° C.
• Add the oleaginous phase slowly to the aqueous phase, stirring constantly.
• Remove from heat and stir the mixture until it congeals.

What is the pH of ointment bases?

Ointments prepared by incorporating five per cent ethyl aminobenzoate in Hydrophilic Ointment U. S. P. were buffered at different pH values ranging from 3.5 to 10.