Table of Contents
What does MyD88 stand for?
View/Edit Human. View/Edit Mouse. Myeloid differentiation primary response 88 (MYD88) is a protein that, in humans, is encoded by the MYD88 gene.
What is the role of MyD88?
Normal Function The MYD88 gene provides instructions for making a protein involved in signaling within immune cells. The MyD88 protein acts as an adapter, connecting proteins that receive signals from outside the cell to the proteins that relay signals inside the cell.
What is MyD88 testing?
Clinical Significance This PCR-based DNA pyrosequencing assay sensitively detects the L265P MYD88 mutation and can be used to help diagnose WaldenstrÖm macroglobulinemia or IgM-expressing lymphoplasmacytic lymphoma and to help in stratifying or subclassifying patients with IgM monoclonal gammopathy.
How is MyD88 activated?
Ligands binding to Toll-like receptor (TLR), interleukin 1 receptor (IL-1R), or IFN-γR1 are known to trigger MyD88-mediated signaling, which activates pro-inflammatory cytokine responses. In addition to monocytes, primary B cells up regulated MyD88 in response to SEA or SEB stimulation.
What is MyD88 deficiency?
MyD88 deficiency is an inherited disorder of the immune system (primary immunodeficiency). This primary immunodeficiency affects the innate immune response, which is the body’s early, nonspecific response to foreign invaders (pathogens).
What do Adaptor proteins do?
Adaptor proteins contain a variety of protein-binding modules that link protein-binding partners together and facilitate the creation of larger signaling complexes. By linking specific proteins together, cellular signals can be propagated that elicit an appropriate response from the cell to the environment.
Is MyD88 a kinase?
Myd88 Dependent Signaling and TRIF Dependent Signaling TAK1, an ubiquitin-dependent kinase of the MAPKKK family, exists in complex with its regulatory subunits TAB1, TAB2, and TAB3 and functions to directly activate two downstream signaling pathways, the NF-κB pathway and MAPKKK signaling (O’Neill and Bowie, 2007).
Is Waldenstrom Macroglobulinemia a non-Hodgkin’s lymphoma?
Waldenstrom macroglobulinemia (WM) is a type of non-Hodgkin lymphoma (NHL). The cancer cells make large amounts of an abnormal protein (called a macroglobulin). Another name for WM is lymphoplasmacytic lymphoma.
What is Waldenstrom syndrome?
Waldenstrom macroglobulinemia (mak-roe-glob-u-lih-NEE-me-uh) is a rare type of cancer that begins in the white blood cells. If you have Waldenstrom macroglobulinemia, your bone marrow produces too many abnormal white blood cells that crowd out healthy blood cells.
Is MyD88 a phosphorylation?
IRF5 directly binds to MyD88 and may be activated by IRAK phosphorylation. Phosphorylation events are shown by gray arrows and polyubiquitination events are shown by black arrows.
How do you test for MYD88 deficiency?
MyD88 deficiency should be suspected in patients with recurrent pyogenic bacterial infections. Diagnosis can be suspected if whole blood cells do not produce inflammatory cytokines upon activation with IL-1beta or Toll-like receptor agonists. Diagnosis can be confirmed by observation of mutations in the MYD88 gene.
What is pyogenic infections?
Infections in which pus is produced are known as pyogenic, that is, pus-producing infections. A wound, whether surgical or accidental, has a tendency to become infected. Strains of Staphylococcus aureus, which are resistant to many of the available antibiotics, are not uncommon in hospitals.