Table of Contents
- 1 What increases methadone metabolism?
- 2 What enzyme metabolizes methadone?
- 3 What foods interact with methadone?
- 4 Which cytochrome metabolizes methadone?
- 5 What antibiotics Cannot be taken with methadone?
- 6 Can you take Keflex with methadone?
- 7 Does caffeine interfere with methadone?
- 8 Is methadone a CYP3A4 inducer?
What increases methadone metabolism?
CYP2B6 induction, either alone (by ritonavir) or co-induction with CYP3A (by rifampin or efavirenz) increased methadone metabolism and clearance.
What enzyme metabolizes methadone?
Methadone undergoes N-demethylation by multiple cytochrome P450 (CYP) enzymes including CYP3A4, CYP2B6, CYP2C19, CYP2D6, CYP2C9, and CYP2C8.
Can I take clindamycin with methadone?
No interactions were found between clindamycin and methadone. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
What foods interact with methadone?
Grapefruit juice can increase the blood levels and effects of methadone. If you regularly consume grapefruits or grapefruit juice, you should be monitored for side effects and/or changes in methadone levels. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.
Which cytochrome metabolizes methadone?
Methadone is metabolized by the cytochrome P450 system being major contributing isoenzymes CYP3A4, CYP2B6 and to a lesser extent CYP2D6 [14].
What does CYP1A2 metabolize?
CYP1A2 metabolizes endogenous compounds such as retinols, melatonin, steroids, uroporphyrinogen and arachidonic acids and plays a major role in procarcinogen activation and DDIs, due to induction and inhibition by several therapeutic drugs.
What antibiotics Cannot be taken with methadone?
Key Messages
| Medicine Classification | Examples | Effect |
|---|---|---|
| Antibiotics | rifampicin | Reduced methadone levels |
| Non-Nucleoside Reverse -Transcriptase Inhibitors | efavirenz, nevirapine | |
| Azole antifungals | fluconazole, ketoconazole | Increased methadone levels |
| Selective serotonin reuptake inhibitors | fluoxetine |
Can you take Keflex with methadone?
Interactions between your drugs No interactions were found between cephalexin and methadone.
Should you eat before taking liquid methadone?
You may take this drug with or without food. If you have nausea, it may help to take this drug with food. Ask your doctor or pharmacist about other ways to decrease nausea (such as lying down for 1 to 2 hours with as little head movement as possible). Carefully measure the dose using a special measuring device/spoon.
Does caffeine interfere with methadone?
Caffeine and Methadone Taking methadone in combination with substances like caffeine can cause an irregular heartbeat, which can have life-threatening risks, especially when your doctor doesn’t know about it. When in doubt about something’s effect on your heart, ask your doctor.
Is methadone a CYP3A4 inducer?
Of particular importance, methadone can induce its own metabolism in a time-dependent fashion via CYP3A4 [2], thus increasing its clearance over time [10,15].
How do you upregulate CYP1A2?
Vegetables such as cabbages, cauliflower and broccoli are known to increase levels of CYP1A2. Lower activity of CYP1A2 in South Asians appears to be due to cooking these vegetables in curries using ingredients such as cumin and turmeric, ingredients known to inhibit the enzyme.