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What is the difference between theoretical and clinical equipoise?
The primary difference between theoretical equipoise and clinical equipoise is that the former requires the physician–researcher to be in a state of uncertainty during all stages of an RCT, whereas the latter requires uncertainty within the expert clinical community.
What is equipoise in a RCT?
Equipoise holds that a patient may be enrolled ethically into a randomized controlled trial (RCT) only when substantial uncertainty surrounds which of the trial treatments would most likely benefit them. Such definitions of equipoise, if literally interpreted, would substantially impede RCT-based clinical research.
What is clinical equipoise quizlet?
clinical equipoise. Theoretical – An individual is completely unsure as to what treatment is better. Clinical – The medical community may reasonably disagree as to which treatment is better.
What is equipoise and why is it important?
Clinical equipoise, also known as the principle of equipoise, provides the ethical basis for medical research that involves assigning patients to different treatment arms of a clinical trial. This applies also for off-label treatments performed before or during their required clinical trials.
What is equipoise in public health research?
The principle of equipoise states that, when there is uncertainty or conflicting expert opinion about the relative merits of diagnostic, prevention, or treatment options, allocating interventions to individuals in a manner that allows the generation of new knowledge (eg, randomization) is ethically permissible.
What is the Common Rule in research?
The Common Rule is the baseline standard of ethics by which any government-funded research in the US is held; nearly all U.S. academic institutions hold their researchers to these statements of rights regardless of funding.
Does equipoise increase appetite?
Thankfully the Equipoise, developed to increase lean body weight appetite in horses, gives my appetite a much-needed boost. Injections become a ritual. Run the vials under hot water to warm the oil. Unwrap a fresh syringe.
What does clinical equipoise mean?
Clinical equipoise. Jump to navigation Jump to search. Clinical equipoise, also known as the principle of equipoise, provides the ethical basis for medical research that involves assigning patients to different treatment arms of a clinical trial. The term was first used by Benjamin Freedman in 1987.
What does Equipoise mean?
definition of equipoise. Definition of equipoise is a highly non-steroidal aromatase inhibitor – an enzyme, whereby in postmenopausal women androstenedione in peripheral tissues is converted into estrone and then to estradiol. Reduced levels of circulating estradiol in breast cancer patients has a therapeutic effect.
Does clinical equipoise exist?
Clinical equipoise exists when the overall benefit or harm offered by the treatment to a patient is uncertain. Clinical equipoise requires ethical conduct when performing clinical trials that involve assigning patients to different treatment arms.