Table of Contents
- 1 What is the purpose of epoetin?
- 2 What is the mechanism of action for epoetin?
- 3 What does Epoetin alfa contain?
- 4 How does epoetin lambda work?
- 5 How is recombinant erythropoietin made?
- 6 What produces erythropoietin and what is the trigger?
- 7 Where does the drug Epoetin Zeta come from?
- 8 Can a androgen increase the response to epoetin alfa?
What is the purpose of epoetin?
EPOETIN ALFA (e POE e tin AL fa) helps your body make more red blood cells. This medicine is used to treat anemia caused by chronic kidney disease, cancer chemotherapy, or HIV-therapy. It may also be used before surgery if you have anemia.
What is the mechanism of action for epoetin?
Erythropoietin (EPO) interacts directly with the EPO receptor on the red blood cell (RBC) surface, triggering activation of several signal transduction pathways, resulting in the proliferation and terminal differentiation of erythroid precursor cells and providing protection from RBC precursor apoptosis.
How do you know epoetin alfa is working?
Your doctor will test your blood regularly—at least weekly at the beginning of your treatment—to make sure EPOGEN® is working. The test will measure your Hb or your hematocrit (hee-MAT-a-crit) levels, though most doctors measure Hb because it is a better way to check for anemia.
What does Epoetin alfa contain?
Each 1 mL of solution contains 10,000 Units of Epoetin alfa, 2.5 mg Albumin (Human), 1.3 mg sodium citrate, 8.2 mg sodium chloride, 0.11 mg citric acid, and 1% benzyl alcohol as preservative in Water for Injection, USP (pH 6.1 ± 0.3). Multidose, Preserved Vial: 1 mL (20,000 Units/mL).
How does epoetin lambda work?
Epoetin lambda (rch) is man-made and works in exactly the same way as the natural hormone produced in your kidneys. Epoetin lambda is a hormone which works by stimulating the production of red blood cells. It is used to treat anaemia, a condition in which there is a decreased number of red blood cells.
What labs values should be monitor with epoetin alfa?
Monitoring and Testing While Taking Epoetin Alfa Tests will include blood tests (specifically hemoglobin and hematocrit) and blood pressure measurements.
How is recombinant erythropoietin made?
Recombinant erythropoietin is a man-made version of natural erythropoietin. It is produced by cloning the gene for erythropoietin. Recombinant erythropoietin drugs are known as erythropoietin-stimulating agents (ESAs).
What produces erythropoietin and what is the trigger?
Erythropoietin (EPO) is a hormone that is produced predominantly by specialised cells called interstitial cells in the kidney. Once it is made, it acts on red blood cells to protect them against destruction. At the same time it stimulates stem cells of the bone marrow to increase the production of red blood cells.
How is epoetin used to treat chronic kidney disease?
Management of anemia in chronic kidney disease (CKD) usually involves repeated administration of epoetin or darbepoetin [erythropoiesis-stimulating agents (ESAs)] to achieve and maintain a higher hemoglobin value.
Where does the drug Epoetin Zeta come from?
With the international nonproprietary name of epoetin zeta, it has been traded subsequently as Silapo ® by Stada (Bad Vilbel, Germany) and as Retacrit ® by Hospira (Lake Forest, IL, USA). Epoetin zeta is produced in Chinese hamster ovary (CHO) cells.
Can a androgen increase the response to epoetin alfa?
Concurrent administration of androgens can increase the patient’s response to epoetin alfa, reducing the amount required to treat anemia. Because of potential adverse effects drug combination should be avoided. Minor (1) oxandrolone increases effects of epoetin alfa by pharmacodynamic synergism. Minor/Significance Unknown.
Is there a way to detect abuse of epoetin alfa?
Abuse by athletes is difficult to detect; no reliable way to distinguish epoetin alfa from the endogenous hormone using readily available drug-screening methods (e.g., immunoradiometric assay).