Table of Contents
What type of cells secrete HCl?
When stimulated, parietal cells secrete HCl at a concentration of roughly 160 mM (equivalent to a pH of 0.8). The acid is secreted into large cannaliculi, deep invaginations of the plasma membrane which are continuous with the lumen of the stomach.
Which type of cells produce and release HCl?
Parietal cells (also called oxyntic cells) are the stomach epithelium cells which secrete gastric acid. Parietal cells produce gastric acid (hydrochloric acid) in response to histamine (via H2 receptors), acetylcholine (M3 receptors) and gastrin (gastrin receptors).
How parietal cells secrete hydrochloric acid?
The tight regulation of parietal cells ensures the proper secretion of HCl. The H+-K+-ATPase enzyme expressed in parietal cells regulates the exchange of cytoplasmic H+ for extracellular K+. The H+ secreted into the gastric lumen by the H+-K+-ATPase combines with luminal Cl- to form gastric acid, HCl.
How is hydrochloric acid produced?
Hydrochloric Acid Production HCl is produced by the parietal cells of the stomach. To begin with, water (H2O) and carbon dioxide (CO2) combine within the parietal cell cytoplasm to produce carbonic acid (H2CO3), which is catalysed by carbonic anhydrase.
What stimulates parietal cells to secrete HCl?
Histamine stimulates the parietal cells to secrete HCl. The gastrin-ECL cell pathway has been investigated extensively in situ (gastric submucosal microdialysis), in vitro (isolated ECL cells) and in vivo (intact animals).
How is HCl secreted?
Hydrochloric acid is the main component of gastric juice and is secreted by the parietal cells of the gastric mucosa in the fundus and corpus. In healthy adults, intragastric pH ranges between 1.5 and 2.5 in the fasting state.
How is HCl produced?
HCl is produced by the parietal cells of the stomach. To begin with, water (H2O) and carbon dioxide (CO2) combine within the parietal cell cytoplasm to produce carbonic acid (H2CO3), which is catalysed by carbonic anhydrase.
How do parietal cells secrete HCl?
Where is hydrochloric acid secreted into Brainly?
Answer: The main constituent of gastric acid is hydrochloric acid produced by parietal cells in the gastric glands in the stomach.
What increases HCl secretion?
As food enters the stomach, acid secretion is further stimulated by distension of the gastric wall as well as by the presence of food and certain beverages. Other factors, such as caffeine, alcohol, and luminal calcium also stimulate HCl secretion.
Why do parietal cells secrete HCl?
Where is hydrochloric acid produced?