Table of Contents
- 1 Which antidepressants are anticholinergic?
- 2 Which antidepressant is least anticholinergic?
- 3 Which SSRI has most anticholinergic side effects?
- 4 Who should not take anticholinergic drugs?
- 5 Is citalopram activating or sedating?
- 6 Is venlafaxine better than citalopram?
- 7 What medications can cause anticholinergic toxicity?
- 8 Can you stay on citalopram for life?
Which antidepressants are anticholinergic?
| Class | Drugs | Relative anticholinergic potency |
|---|---|---|
| Psychotropic | Selective serotonin reuptake inhibitor (SSRI) antidepressants: citalopram, fluoxetine, fluvoxamine, paroxetine* | Low |
| Tricyclic antidepressants: amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline, others | High |
Which antidepressant is least anticholinergic?
SSRIs are the initial antidepressants of choice for uncomplicated depression because of their minimal anticholinergic effects. They have the advantage of ease of dosing and low toxicity in overdose.
Which antidepressant has the most anticholinergic effect?
Researchers found that the following types of anticholinergic medications carried the highest risk:
- Antidepressants, such as amitriptyline and paroxetine.
- Bladder disorder medications, such as oxybutynin and tolterodine.
- Antiparkinson medications, such as benztropine and procyclidine.
Which SSRI has most anticholinergic side effects?
A comparison of ED(50) values showed that the ratio of anticholinergic effect to antidepressant activity was fluvoxamine, >3.2; paroxetine, 2.1-2.6; clomipramine, <0.8. These results suggest that paroxetine may induce fewer adverse anticholinergic effects than clomipramine, but more than fluvoxamine.
Who should not take anticholinergic drugs?
Anticholinergic drugs should not be used in conditions such as:
- benign prostatic hypertrophy (BPH)
- angle closure glaucoma.
- myasthenia gravis.
- Alzheimer’s disease.
- bowel blockage.
- urinary tract blockage or urinary hesitancy.
Does citalopram cause Alzheimer’s?
Another study published last year from researchers in Taiwan also linked SSRIs with an increased risk of dementia. However, a U.S. team reported two years ago the SSRI citalopram (sold under the brand name Celexa) appeared to reduce production of the deadly brain plaques tied to Alzheimer’s.
Is citalopram activating or sedating?
Although all SSRIs can cause sedation. The most sedating SSRIs are Luvox (fluvoxamine), Paroxetine (Paxil), and Citalopram (Celexa). Increasing daytime exercise can also be beneficial.
Is venlafaxine better than citalopram?
The reduction rates of the Hamilton Anxiety (HAMA) scale show that the efficacy of venlafaxine was significantly better than that of citalopram by the end of week 12. The findings of this study suggest that venlafaxine is more cost-effective than citalopram in the treatment of outpatients with GAD.
What are some examples of anticholinergic drugs?
Examples of these drugs include:
- atropine (Atropen)
- belladonna alkaloids.
- benztropine mesylate (Cogentin)
- clidinium.
- cyclopentolate (Cyclogyl)
- darifenacin (Enablex)
- dicylomine.
- fesoterodine (Toviaz)
What medications can cause anticholinergic toxicity?
Examples of such classes of medications that frequently cause strong anticholinergic effects include antiemetics, antispasmodics, bronchodilators, antiarrhythmics, antihistamines, various analgesics, antihypertensives, antiparkinsonian agents, corticosteroids, skeletal and smooth muscle relaxants, antiulcer drugs, and …
Can you stay on citalopram for life?
For most people, citalopram is safe to take for a long time. A few people may get sexual side effects, such as problems getting an erection or a lower sex drive. In some cases these can continue even after stopping the medicine.