Table of Contents
What is the formulation of nasal spray?
Nasal spray formulations may be water-based, hydroalcoholic, nonaqueous, suspensions, or emulsions. A formulation can include diverse excipients, including solvents, mucoadhesive agents, buffers, antioxidants, preservatives, and penetration enhancers (i.e., compounds to improve absorption or penetration).
What is benzalkonium chloride in nasal spray?
Benzalkonium chloride (BKC) is a quaternary ammonium antimicrobial agent included in some nasal solutions (including glucocorticosteroids) to prevent the growth of bacteria.
What is the active ingredient in nasal saline spray?
Saline Nasal Spray
| Active Ingredient/Active Moiety | ||
| Ingredient Name | Basis of Strength | Strength |
|---|---|---|
| SODIUM CHLORIDE (UNII: 451W47IQ8X) (CHLORIDE ION – UNII:Q32ZN48698) | SODIUM CHLORIDE | 6.5 mg in 1 mL |
What chemicals are in nasal spray?
Nasal decongestant sprays contain such ingredients as oxymetazoline (e.g., Afrin), phenylephrine (e.g., Neo-Synephrine), or naphazoline (limited availability).
What is a saline spray?
A saline nasal spray is a simple saltwater solution that can be used by both children and adults. 1 It may help give you relief from nasal dryness (helping prevent nosebleeds), congestion associated with the common cold or allergies, or even snoring.
What are parenteral suspensions?
Parenteral suspensions are dosage forms containing drugs having low solubility. Drugs in suspension form increase the solubility, stability of the drugs. Drugs in sulfonation form have large surfaces areas. Parenteral suspensions provides onset of action for prolonged line on compared to solution.
What is BKC chemical?
Infobox references. Benzalkonium chloride (BZK, BKC, BAK, BAC), also known as alkyldimethylbenzylammonium chloride (ADBAC) and by the trade name Zephiran, is a type of cationic surfactant. It is an organic salt classified as a quaternary ammonium compound.
What is xylometazoline hydrochloride?
Xylometazoline is a sympathomimetic agent acting on alpha-adrenergic receptors in the nasal mucosa. Administered in the nose, it constricts the nasal blood vessels, thereby decongesting the mucosa of the nose and neighbouring regions of the pharynx.
Does nasal spray contain epinephrine?
The epinephrine nasal spray had a higher peak of epinephrine concentration compared to the 0.3 mg dose, but 16% lower compared to 0.5 mg doses. Overall, the epinephrine nasal spray delivered a more consistent exposure and hemodynamic response within the first 20 minutes.
What ingredients are in Afrin?
Active Ingredients: Oxymetazoline Hydrochloride (0.05 %), Nasal Decongestant. Inactive Ingredients: Benzalkonium Chloride Solution, Benzyl Alcohol, Camphor, Edetate Disodium, Eucalyptol, Menthol, Polysorbate 80, Propylene Glycol, Purified Water, Sodium Phosphate Dibasic, Sodium Phosphate Monobasic.
What are the ingredients of Afrin nose spray?
How do you make Melanotan nasal spray?
How to mix Melanotan Nasal spray?
- Open the bottle with Melanotan then clean the top using alcohol swab.
- Open the sterile water ampoule and fill the syringe to the maximum.
- Stick the syringe into the Melanotan bottle then push the water into it.
- Do the last two steps again.