Table of Contents
- 1 What are the properties of atorvastatin?
- 2 What is the chemical structure of atorvastatin?
- 3 What functional groups are in atorvastatin?
- 4 How is atorvastatin excreted?
- 5 How is atorvastatin excreted from the body?
- 6 What is the mechanism of action of atorvastatin?
- 7 How does Atorvastatin work in the body?
- 8 Is Atorvastatin a prodrug?
- 9 Which is the calcium salt in atorvastatin?
- 10 What is the half life of atorvastatin?
- 11 What is the role of atorvastatin in the environment?
What are the properties of atorvastatin?
Atorvastatin (Lipitor) is a member of the drug class known as statins. It is used for lowering cholesterol….Structure for T3D4980: Atorvastatin.
| Property | Value |
|---|---|
| Melting Point | 159.2-160.7 °C |
| Boiling Point | Not Available |
| Solubility | Sodium salt soluble in water, 20.4 ug/mL (pH 2.1), 1.23 mg/mL (pH 6.0) |
| LogP | 5.7 |
What is the chemical structure of atorvastatin?
Atorvastatin calcium
| PubChem CID | 60822 |
|---|---|
| Structure | Find Similar Structures |
| Chemical Safety | Laboratory Chemical Safety Summary (LCSS) Datasheet |
| Molecular Formula | C66H68CaF2N4O10 |
| Synonyms | ATORVASTATIN CALCIUM 134523-03-8 Lipitor Sortis Tahor More… |
What is function of atorvastatin?
Atorvastatin belongs to a group of medicines called statins. It’s used to lower cholesterol if you’ve been diagnosed with high blood cholesterol. It’s also taken to prevent heart disease, including heart attacks and strokes.
What functional groups are in atorvastatin?
The molecular structure of Lipitor also contains functional groups we know. Hydroxyl groups, benzene rings, carboxylic acids, amines, and ketones…the gang’s all here.
How is atorvastatin excreted?
Excretion: Atorvastatin and its metabolites are eliminated by biliary secretion. Less than 2% of the drug is passed in urine.
How is atorvastatin metabolised?
Atorvastatin acid is extensively metabolised in both the gut and liver by oxidation, lactonisation and glucuronidation, and the metabolites are eliminated by biliary secretion and direct secretion from blood to the intestine.
How is atorvastatin excreted from the body?
What is the mechanism of action of atorvastatin?
Mechanism of Action Atorvastatin competitively inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. [2] By preventing the conversion of HMG-CoA to mevalonate, statin medications decrease cholesterol production in the liver.
Why does atorvastatin cause muscle pain?
Statin medications and low cholesterol levels can both contribute to low CoQ10 levels. Calcium leakage. Calcium helps muscles contract, but when calcium leaks from muscle cells unintentionally, it can damage your muscle cells which causes muscle pain.
How does Atorvastatin work in the body?
Atorvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
Is Atorvastatin a prodrug?
Unlike the previously introduced prodrugs , lovastatin and simvastatin, which are inactive till get metabolised, atorvastatin is an active compound. The statins inhibit competitively an enzyme (HMG-CoA reductase) in the liver that converts HMG-CoA to mevalonic acid, an early precursor of cholesterol.
What are the metabolites of Atorvastatin?
Which is the calcium salt in atorvastatin?
Atorvastatin Calcium is the calcium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis.
What is the half life of atorvastatin?
Atorvastatin, cerivastatin (withdrawn from clinical use in 2001), fluvastatin, pitavastatin and rosuvastatin are fully synthetic compounds, with elimination half-lives ranging from 1 h for fluvastatin to 19 h for rosuvastatin. Atorvastatin, simvastatin, lovastatin, fluvastatin, cerivastatin and pitavastatin are relatively lipophilic compounds.
Are there any side effects to taking atorvastatin?
Myotoxic side effects, including myopathy or rhabdomyolysis, have been observed with the usage of atorvastatin calcium. Painful myalgia with a significant creatine kinase release (> 2000 IU/l) is also associated with the use of atorvastatin [35].
What is the role of atorvastatin in the environment?
It has a role as an environmental contaminant and a xenobiotic. It is an aromatic amide, a member of monofluorobenzenes, a statin (synthetic), a dihydroxy monocarboxylic acid and a member of pyrroles. It derives from a heptanoic acid. It is a conjugate acid of an atorvastatin (1-).