How much Depakote is lethal?

How much Depakote is lethal?

400 — 1000 mg/kg: severe toxicity, i.e. Coma. >1g/kg: potentially life threatening, i.e. profound coma, multi-organ toxicity including hypotension, metabolic (lactic) acidosis, cerebral oedema, biochemical abnormalities, bone marrow suppression.

Is 3000 mg of Depakote too much?

Most patients take a total of 750 to 3,000 mg each day. Taking more than 4,000 mg per day is seldom recommended. Patients who have been taking regular Depakote or Depakene will need to take 8% to 20% more Depakote ER to achieve the same effect.

Is 2500 mg of Depakote too much?

Depakote tablets are administered orally. The recommended starting dose is 250 mg twice daily. Some patients may benefit from doses up to 1,000 mg/day. In the clinical trials, there was no evidence that higher doses led to greater efficacy.

Is 2000 mg of Depakote too much?

The mean daily dose usually ranges between 1000 – 2000 mg valproate. Patients receiving daily doses higher than 45 mg/kg/day body weight should be carefully monitored. Continuation of treatment of manic episodes in bipolar disorder should be adapted individually using the lowest effective dose.

What happens if you OD on Depakote?

An overdose of Depakote could be fatal, so seek immediate help or call the Poison Help Line at 1-800-222-1222 if you overdose. Overdose symptoms can include irregular heartbeat, sleepiness, and loss of consciousness resulting in a coma.

Can I take 1500 mg of Depakote?

Maintenance dosage in usually in the range of 1000-1500 mg. daily, sometimes higher. The target blood level is 50-100 micrograms/milliliter of blood, though some people’s symptoms are best controlled at slightly lower or higher levels.

Can you OD on Depakote?

Is it possible to OD on Depakote?

What is too much Depakote?

Never take too much Depakote or stop suddenly without your doctor’s advice. Symptoms of overdosage of Depakote include changes in consciousness, fainting, and slow or irregular heartbeat.

What is the maximum amount of Depakote you can take?

Dosage formulations for acute bipolar mania

	DEPAKOTE Delayed-Release Tablets	DEPAKOTE ER Tablets
MAXIMUM RECOMMENDED DOSE	60 mg/kg/day
THERAPEUTIC BLOOD RANGE	Clinical response was dosed at trough plasma concentrations between 50-125 μg/mL	85 to 125 μg/mL