Is phenytoin hard on the liver?

Is phenytoin hard on the liver?

Phenytoin is an anticonvulsant that in rare cases can cause acute idiosyncratic drug-induced liver disease that can be severe or even fatal. The liver injury caused by phenytoin appears to be due to a hypersensitivity reaction and resembles cases of immunoallergic hepatotoxicity.

Which seizure medication can have a toxic effect on the liver?

Drugs such as valproic acid, phenytoin, and felbamate, have a well-recognized association with liver toxicity.

Is Dilantin metabolized by the liver?

Phenytoin is highly (>90%) protein-bound and is extensively metabolized by the liver. Less than 5% of the drug is excreted unchanged in the liver. Phenytoin exhibits nonlinear (e.g., Michaelis-Menton) pharmacokinetics, indicating that the metabolismsaturates at doses given clinically.

How do you know if there’s something wrong with your liver?

If signs and symptoms of liver disease do occur, the may include:

• Skin and eyes that appear yellowish (jaundice)
• Abdominal pain and swelling.
• Swelling in the legs and ankles.
• Itchy skin.
• Dark urine color.
• Pale stool color.
• Chronic fatigue.
• Nausea or vomiting.

How do you treat liver damage due to medication?

What is the treatment for drug-induced liver disease? The most important treatment for drug-induced liver disease is stopping the drug that is causing the liver disease. In most patients, signs and symptoms of liver disease will resolve and blood tests will become normal and there will be no long-term liver damage.

Can vimpat cause liver damage?

See “What is the most important information I should know about VIMPAT?” VIMPAT may cause other serious side effects including: A serious allergic reaction that may affect your skin or other parts of your body such as your liver or blood cells.

Can antiepileptic drugs cause elevated liver enzymes?

Such AEDs (CBZ, PHT and VPA) are associated with mild elevations of liver enzymes, which may occur in up to 50% of patients. These elevations are usually transitory or dose-related and do not appear to be associated with hepatocellular injury.

What is adverse effect of phenytoin?

Headache, nausea, vomiting, constipation, dizziness, feeling of spinning, drowsiness, trouble sleeping, or nervousness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Phenytoin may cause swelling and bleeding of the gums.

Can a high Dilantin level cause kidney damage?

Elevated Dilantin levels can cause inability to walk, liver and kidney damage. 40 years seems like a long time on the same med.

What happens if you take Dilantin for 40 years?

Try something else. Elevated Dilantin levels can cause inability to walk, liver and kidney damage. 40 years seems like a long time on the same med. You are really jeopardizing your liver/life by taking 25 Tylenol in a 24 hour period.

What happens if you take Tylenol with Dilantin?

Elevated Dilantin levels can cause inability to walk, liver and kidney damage. 40 years seems like a long time on the same med. You are really jeopardizing your liver/life by taking 25 Tylenol in a 24 hour period. Excess amounts of the drug are extremely liver toxic.

How is Keppra and Dilantin causing liver damage?

The doctor says it has to be the Dilantin causing the liver damage because Keppra doesn’t get processed through the liver. My husband doesn’t drink enough water (he sometimes goes hours and hours without peeing during the day)…could that cause elevated ammonia levels?