What causes appositional bone growth?

What causes appositional bone growth?

The process of appositional growth occurs when the cartilage model also grows in thickness due to the addition of more extracellular matrix on the peripheral cartilage surface, which is accompanied by new chondroblasts that develop from the perichondrium.

What is responsible for Appositional growth?

Appositional growth is the increase in the diameter of bones by the addition of bony tissue at the surface of bones. Osteoblasts at the bone surface secrete bone matrix, and osteoclasts on the inner surface break down bone. The osteoblasts differentiate into osteocytes.

What hormone increases cartilage formation and bone growth?

The estrogen produced in children and early in puberty can increase bone growth. The high concentration that occurs at the end of puberty has a special effect—that is, to stop further growth in height by closing the cartilage plates at the ends of long bone that previously had allowed the bones to grow in length.

What is interstitial growth of cartilage?

Interstitial growth is the increase in the length of bones by the cartilage lengthening and is replacing by bone tissue while appositional growth is the increase in the diameter of bones by the addition of bony tissue at the surface of the pre-existing bone.

What chemical does an osteoblast release that deactivates an osteoclast?

Calcitonin, a hormone of thyroid gland, suppresses the osteoclastic activity. The osteoclasts do not have receptors for parathyroid hormone (PTH). However, PTH stimulates the osteoblasts to secrete the cytokine called osteoclast-stimulating factor, which is a potent stimulator of the osteoclastic activity.

What is interstitial growth?

Interstitial growth is the process that adds or removes solid mass at locations inside a solid material. For this process to occur, there must be interstitial space within this material to allow atoms or molecules to bind to the underlying substrate.

What is interstitial growth in bones?

Interstitial growth is a bone growth which results in the lengthening of the bone. This growth occurs within the lacunae. It happens due to the cell division in the proliferative zone and the maturation of cells in the zone of maturation. Cartilage lengthens and is replaced by bone tissue during interstitial growth.

What hormone helps bone growth?

Bone and mineral metabolism is regulated by numerous hormones and local growth factors. Growth hormone (GH), directly and/or indirectly through local IGF1 and IGF2 production, stimulates bone turnover as it increases osteoblast number and function.

What is interstitial growth in bone?

How does interstitial growth of cartilage occur?

Cartilage can grow in two ways: Interstitial growth – chondrocytes grow and divide and lay down more matrix inside the existing cartilage. Appositional growth – new surface layers of matrix are added to the pre-existing matrix by new chondroblasts from the perichondrium.

How is cartilage replaced in endochondral ossification?

In endochondral ossification, bone develops by replacing hyaline cartilage. Cartilage does not become bone. Instead, cartilage serves as a template to be completely replaced by new bone. Endochondral ossification takes much longer than intramembranous ossification.

How are cartilage and chondrocytes related to bone formation?

While these deep changes are occurring, chondrocytes and cartilage continue to grow at the ends of the structure (the future epiphyses), which increases the structure’s length at the same time bone is replacing cartilage in the diaphyses.

Which is the primary ossification center of cartilage?

(1)Cartilage matrix is calcified and chondrocytes die. (2)Chondrocytes hypertrophy. (3)Cartilage model is formed. (4)Osteoblasts deposit bone on the surface of the calcified cartilage called the primary ossification center.

Where do osteoblasts deposit bone on the cartilage?

(4)Osteoblasts deposit bone on the surface of the calcified cartilage called the primary ossification center. (5)Blood vessels from the periosteum invade calcified cartilage bringing in osteoblasts and osteoclasts. Which of the following statements about bone growth is TRUE?