Table of Contents
What causes excessive cell division?
Examples are discussed of human cancers in which increased cell division, which drives the accumulation of genetic errors and can lead to neoplastic transformation, is caused by hormones, drugs, infectious agents, chemicals, physical or mechanical trauma, and other chronic irritation.
What could uncontrolled mitosis lead to?
Cancer is basically a disease of uncontrolled cell division. Its development and progression are usually linked to a series of changes in the activity of cell cycle regulators.
What is an example of abnormal mitosis?
In addition to the direct damage to chromosomal integrity, abnormal mitosis also exerts indirect effects on the future stability of the genome. For example, chromosome missegregation and the generation of aneuploidy are common byproducts of abnormal mitosis and may occur without any immediate acquisition of DNA damage.
What happens if mitosis happens too often than normal?
Mistakes during mitosis lead to the production of daughter cells with too many or too few chromosomes, a feature known as aneuploidy. Nearly all aneuploidies that arise due to mistakes in meiosis or during early embryonic development are lethal, with the notable exception of trisomy 21 in humans.
What if rapid mitosis occurs?
When Mitosis Occurs Most Rapidly A high rate of mitosis is required to grow and repair tissue, such as in human lymph nodes and bone marrow.
What disease is associated with mitosis?
Correct alignment of the mitotic spindle during cell division is crucial for cell fate determination, tissue organization, and development. Mutations causing brain diseases and cancer in humans and mice have been associated with spindle orientation defects.
What type of disease may result if cell division is not properly regulated?
Disruption of normal regulation of the cell cycle can lead to diseases such as cancer. When the cell cycle proceeds without control, cells can divide without order and accumulate genetic errors that can lead to a cancerous tumor .
What causes uncontrolled cell division?
Cancer is unchecked cell growth. Mutations in genes can cause cancer by accelerating cell division rates or inhibiting normal controls on the system, such as cell cycle arrest or programmed cell death. As a mass of cancerous cells grows, it can develop into a tumor.