Table of Contents
What is gastric Cytoprotection?
The term ‘cytoprotection’ means protection against gastric mucosal injury by a mechanism other than inhibition or neutralisation of gastric acid.
What is the cytoprotective effect?
Cytoprotective agents stimulate mucus production and enhance blood flow throughout the lining of the gastrointestinal tract. These agents also work by forming a coating that protects the ulcerated tissue.
What are ulcer healing drugs?
Medications that block acid production and promote healing. These drugs include the prescription and over-the-counter medications omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), esomeprazole (Nexium) and pantoprazole (Protonix).
What medication is used for management of gastric ulcers and works by coating the ulcers and protecting them from peptic acid?
Bismuth subsalicylates. Medicines containing bismuth subsalicylate link, such as Pepto-Bismol, coat a peptic ulcer and protect it from stomach acid. Although bismuth subsalicylate can kill H. pylori, doctors sometimes prescribe it with antibiotics, not in place of antibiotics.
What are side effects of sucralfate?
Constipation, dry mouth, upset stomach, gas, and nausea may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
Does sucralfate stop acid reflux?
Carafate (sucralfate) is an anti-ulcer drug used to treat ulcers of the upper gastrointestinal tract, peptic ulcer disease, to prevent recurrent ulcers after the ulcer has healed, to relieve or prevent ulcers caused by nonsteroidal anti-inflammatory drugs (NSAIDs), and to treat gastroesophageal reflux disease (GERD).
What causes peptic ulcer?
The most common causes of peptic ulcers are infection with the bacterium Helicobacter pylori (H. pylori) and long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve).
How do u know if you have ulcers?
Some people with ulcers don’t experience any symptoms. But signs of an ulcer can include: Gnawing or burning pain in your middle or upper stomach between meals or at night. Pain that temporarily disappears if you eat something or take an antacid.
What causes cytoprotection in the gastrointestinal tract?
Cytoprotection requiring both a glycolytic substrate and an ATP synthase inhibitor indicates cytotoxicity caused by mitochondrial uncoupling as occurs, for example, for calcium ionophore toxicity and oxidative stress (Imberti et al. 1993; Prostanoids provide cytoprotection in the gastrointestinal tract by a number of mechanisms.
What’s the difference between cytoprotection and detoxification?
The term cytoprotection is used here to differentiate between the indirect protection afforded by detoxification of reactive oxygen species initiated by xenobiotics and the direct detoxification of xenobiotic reactive metabolites discussed above under detoxification.
Why is CEPT a useful strategy for cytoprotection?
Thus, CEPT represents a unique poly-pharmacological strategy for comprehensive cytoprotection, providing a rationale for efficient and safe utilization of hPSCs. Pluripotency is a remarkable cellular state that allows unlimited self-renewal and differentiation into all cell types found in the human body.