Table of Contents
What is the difference between atherosclerosis and atherothrombosis?
Although an atherosclerotic plaque may remain clinically silent, it is prone to disruption, leading to local platelet activation and aggregation. Therefore, the major complication of atherosclerosis is thrombosis, with local occlusion or distal embolism – a generalized disease process known as atherothrombosis.
What causes atherothrombosis?
Atherothrombosis is a complication of atherosclerosis. The essence of this process consists of closing or narrowing vessel lumen, which is caused by a clot formation following exposure of thrombogenic, lipid rich necrotic core, of the ruptured plaque.
What is an atherothrombotic disease?
Atherothrombotic vascular disease (AVD) is a systemic, diffuse condition involving the coronary and peripheral arteries, and is the most common cause of death and disability worldwide.
What the meaning of atherosclerosis?
Atherosclerosis is the buildup of fats, cholesterol and other substances in and on your artery walls. This buildup is called plaque. The plaque can cause your arteries to narrow, blocking blood flow.
What causes claudication?
Claudication is pain in the legs or arms that comes on with walking or using the arms. This is caused by too little blood flow to your legs or arms. Claudication is usually a symptom of peripheral artery disease, in which the arteries that supply blood to your limbs are narrowed, usually because of atherosclerosis.
What is the medical definition of atherothrombosis?
Medical Definition of atherothrombosis : the formation of a blood clot within an artery as a result of atherosclerosis As with any drug used to prevent atherothrombosis, vascular events are frequent among patients treated with aspirin or other antiplatelet drugs, and this phenomenon is sometimes described as treatment failure.
What is the percentage of stroke caused by atherothrombosis?
Ischaemic stroke accounts for 80% of strokes and atherothrombosis accounts for approximately 20% of all strokes. Criteria for atherothrombotic stroke are evidence of a 50% (or greater) stenosis of a cervical artery and exclusion of other potential causes.
Is the atherosclerotic and thrombotic processes interdependent?
The atherosclerotic and thrombotic processes appear to be interdependent and could therefore be integrated under the term “atherothrombosis”, a broader term that includes both atherosclerosis and its thrombotic complications ( Fig. 1 ). 1,6 Normal and abnormal endothelial function.
Which is a major complication of atherosclerosis?
Therefore, the major complication of atherosclerosis is thrombosis, with local occlusion or distal embolism – a generalized disease process known as atherothrombosis. The three main clinical manifestations of atherothrombosis are coronary heart disease (myocardial infarction and angina), peripheral arterial disease and cerebral ischaemia.