Table of Contents
What level is IgG deficiency?
Serum IgG levels reduced by more than 2 SDs below the mean, accompanied by deficiencies in IgA and/or IgM, suggest common variable immunodeficiency. Usually the IgG level is less than 400 mg/dL; 70% of patients will have very low or absent IgA content.
What is an IgG deficiency?
An IgG deficiency is a health problem in which your body doesn’t make enough immunoglobulin G (IgG). Normally, IgG is the most abundant antibody in the blood. It helps prevent infections. So, people with IgG deficiency are more likely to get infections.
What is IgG normal range?
Normal Ranges Adult: IgG 6.0 – 16.0g/L. IgA 0.8 – 3.0g/L. IgM 0.4 – 2.5g/L.
What is a low immunoglobulin number?
Low levels of immunoglobulins mean your immune system isn’t working as well as it should. This can be caused by: Medicines that weaken your immune system, such as steroids. Diabetes complications. Kidney disease or kidney failure.
What kind of doctor treats IgG deficiency?
You’ll likely start by seeing your family doctor or a general practitioner. You might then be referred to a doctor who specializes in disorders of the immune system (immunologist).
What are normal IgG subclass levels?
Adult reference range: IgG1 = 3.80 – 9.30g/L. IgG2 = 2.40 – 7.00g/L. IgG3 = 0.20 – 1.80g/L.
How is IgG deficiency diagnosed?
A blood test that measures immunoglobulin levels can diagnose IgG deficiency. It’s possible to have a normal level of total IgG, so the testing of the IgG subclasses is important. Tests can also be done on saliva and cerebrospinal fluid. But, a blood test is the most common.
How is IgG deficiency treated?
Currently, the accepted therapy for IgG deficiency is the intravenous administration of 300-600 mg/kg of IgG once every 3-4 weeks, or 100-200 mg/kg/wk subcutaneously. Higher doses have been shown to be more effective in reducing infections in patients with histories of chronic or recurrent sinopulmonary infections.
What does immunoglobulin G do?
IgG has 4 different subclasses, IgG1— 4. IgG is always there to help prevent infections. It’s also ready to multiply and attack when foreign substances get into the body. When you don’t have enough, you are more likely to get infections.
What does high immunoglobulin G mean?
High levels of IgG may mean a long-term (chronic) infection, such as HIV, is present. Levels of IgG also get higher in IgG multiple myeloma, long-term hepatitis, and multiple sclerosis (MS).
What is the treatment for IgG deficiency?
Can low IgG be temporary?
IgG subclass deficiencies IgG1 tends to compensate in the first few years of life, but this may fail temporarily and cause ‘transient hypogammaglobulinemia of infancy’ and recurrent infections.