Why is glyburide not recommended?

Why is glyburide not recommended?

Glyburide, a second-generation sulfonylurea, is associated with hypoglycemia more often than most other sulfonylureas. Currently, glyburide is not recommended for patients with renal impairment (creatinine clearance of less than 50 mL/min) or severe hepatic impairment because of the risk of hypoglycemia.

When should you not use glyburide?

Glyburide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).

Who should not take glyburide?

For people with diabetic ketoacidosis: Don’t use glyburide. Diabetic ketoacidosis is a serious complication of diabetes. It should be treated with insulin. For people with type 1 diabetes: Don’t use glyburide for the treatment of type 1 diabetes.

Why is glyburide a high risk medication?

Glyburide has been associated with an increased risk for hypoglycemia and long-term cardiovascular mortality. This may be due to differences in tissue-specific binding of the respective sulfonylureas.

What can I use instead of glyburide?

Glyburide / Metformin Alternatives

• Glucovance (glyburide / metformin) Prescription only.
• 8 alternatives.
• Metaglip (metformin / glipizide) 1 dosage forms.
• Byetta (exenatide) Prescription only.
• Januvia (sitagliptin) Prescription only.
• Nesina (alogliptin) Prescription only.
• Precose (acarbose)
• Glucotrol (glipizide)

Is glyburide hard on the kidneys?

Glyburide use should be avoided in patients with severe kidney impairment as defined by a GFR of less than 60 mL/min (CKD stage 3 and below). Because 50 percent of the glyburide is excreted by the kidneys, the drug can build up in people with CKD, causing low blood sugar levels.

What is the safest drug for type 2 diabetes?

Metformin is still the safest and most effective type 2 diabetes medication, said Bolen.

What is the best medicine to lower A1C?

Invokana (sodium glucose cotransporter 2 inhibitor class) This medication has been shown to lower A1C levels by 0.7% to 1% but is particularly favored by most patients because of the significant weight loss it can bring about.

Can you just stop taking glyburide?

Glyburide and metformin combination controls diabetes but does not cure it. Continue to take glyburide and metformin even if you feel well. Do not stop taking glyburide and metformin without talking to your doctor.

Can you cut glyburide in half?

Glyburide Tablets, USP (micronized) can be divided in half for a more flexible dosing regimen. Press gently on the score and the tablet will split in even halves.

Do you have to take glyburide if you have diabetes?

Glyburide helps control blood sugar but does not cure diabetes. Continue to take glyburide even if you feel well. Do not stop taking glyburide without talking to your doctor. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. What special precautions should I follow?

What happens if you take too much glyburide?

Too much glyburide can cause low blood sugar ( hypoglycemia) when it is used under certain conditions. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). Different people may feel different symptoms of low blood sugar.

How does glyburide lower your risk of heart attack?

Proper control of diabetes may also lessen your risk of a heart attack or stroke. Glyburide belongs to the class of drugs known as sulfonylureas. It lowers blood sugar by causing the release of your body’s natural insulin.

How long does it take for glyburide to lower blood sugar?

Depending on whether you are taking the non-micronized (Diabeta) or the micronized (Glynase) formulation of the medication will determine how long it takes for the medication to work. Generally, Diabeta (glyburide) lowers your blood sugar anywhere from 15 to 60 minutes after taking the dose.