Table of Contents
What is simvastatin made of?
ZOCOR (simvastatin) is a lipid-lowering agent that is derived synthetically from a fermentation product of Aspergillus terreus. After oral ingestion, simvastatin, which is an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form.
Why is simvastatin bad?
Their review found statins decrease energy and fitness, and increase fatigue and sleep problems. They also found that statins may increase the risk of muscle aches and pains, kidney and liver problems, bleeding in the brain, and type 2 diabetes.
What are the bad side effects of simvastatin?
Simvastatin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- constipation.
- stomach pain.
- nausea.
- headache.
- memory loss or forgetfulness.
- confusion.
- itchy or red skin.
What should you not take with simvastatin?
Do not use more than 20 mg per day of simvastatin together with amiodarone (Cordarone®), amlodipine (Norvasc®), lomitapide (Juxtapid™), or ranolazine (Ranexa®). When used together with higher doses of simvastatin, these medicines may increase your risk of muscle injury and could result in kidney problems.
What is the pKa of simvastatin?
These are hydroxy acids with a 6 to 12 carbon atoms long side chain. Simvastatin is a hypolipidemic drug used to control elevated cholesterol, or hypercholesterolemia….3D Structure for HMDB0061047 (simvastatin hydroxy acid)
| Property | Value | Source |
|---|---|---|
| pKa (Strongest Acidic) | 4.21 | ChemAxon |
| pKa (Strongest Basic) | -2.7 | ChemAxon |
Is simvastatin soluble?
Simvastatin is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of simvastatin in ethanol is approximately 20 mg/ml and approximately 30 mg/ml in DMSO and DMF. Simvastatin is sparingly soluble in aqueous buffers.
Does simvastatin cause weight gain?
As with many medications, statins may cause side effects, including digestive problems, muscle pain and weakness, and cognitive dysfunction. Another side effect that’s been linked to statins is weight gain.
Can simvastatin be crushed?
Atorvastatin, rosuvastatin and simvastatin tablets Can be crushed and/or dispersed in water or crushed and given with soft food. They are film-coated and may taste bitter or unpleasant.
What’s the difference between Crestor and simvastatin?
Simvastatin (Zocor) and Crestor (rosuvastatin) are both in the statin family of cholesterol-reducing drugs. They both work to lower “bad” cholesterol in the bloodstream, which comes in the form of low-density lipoprotein or LDL.
What’s the generic name for the drug simvastatin?
Simvastatin. Generic Name: simvastatin (SIM va sta tin) Brand Name: Zocor. Medically reviewed by Sanjai Sinha, MD. Last updated on Nov 2, 2020. Uses. Warnings. Dosage. What to avoid.
What kind of lipid lowering agent is simvastatin?
Simvastatin is a lipid-lowering agent that is derived synthetically from a fermentation product of Aspergillus terreus. After oral ingestion, Simvastatin, which is an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form.
How can I lower the cost of simvastatin?
Here are some ways that may lower the cost of your simvastatin prescription. You may be able to lower your total cost by filling a greater quantity at one time. Cut a higher-dosage pill in half to save 50% or more. Are there any restrictions on coverage?